We investigated how choline magnesium trisalicylate (CMT) helps alleviate bone pain in patients with metastatic cancer. In a carefully designed study involving 26 participants, we compared CMT against a placebo in a crossover format, measuring pain relief at multiple intervals after dosing.
While we observed a significant reduction in pain just one hour post-treatment with CMT, other comparisons showed improvements that didn't reach statistical significance. This suggested that CMT might assist in managing bone pain, potentially complementing traditional opioids, but overall effectiveness is still under exploration.
Read More
7
Pamidronate therapy reduces bone pain
New trends in the treatment of osteogenesis imperfecta type III - own experience.
We evaluated the effects of pamidronate therapy on children with osteogenesis imperfecta type III. Over the course of treatment, we saw reductions in bone pain, alongside a significant decrease in fracture incidence.
The therapy positively impacted children's daily activities and their overall mobility. Importantly, the treatment was found to be safe, although some patients experienced mild side effects like low calcium levels and a fever. Overall, our findings suggest that bisphosphonate therapy is beneficial for management in these young patients.
Read More
7
Promising drug delivery for osteoporosis
Synthesis and characterization of novel denosumab/magnesium-based metal organic frameworks nanocomposite prepared by ultrasonic route as drug delivery system for the treatment of osteoporosis.
We developed a novel drug delivery system combining denosumab and magnesium within metal-organic frameworks to target osteoarthritis. The framework showed good potential for loaded drug release, delivering about 72% of denosumab in just 8 hours.
Additionally, it released magnesium ions, which are beneficial for bone formation. Our cytotoxicity tests demonstrated that the system is biocompatible and encourages cell growth over time. While our findings are promising for pain relief linked to osteoporosis, further studies are needed to confirm effectiveness in real-world scenarios.
Read More
Most Useful Reviews
9
Effective for calm
109 people found this helpful
Best Mg I've ever used! This magnesium is great! I'm a naturopath and have tried many types of magnesium. This one genuinely induces a sense of calm, balance and prepares me for sound sleep through the night. Within a few days, I noticed a change. It's been about three weeks now and my neck/muscle pain has disappeared. Very happy with this product. Thank you!
Read More
9
Chronic pain relief
48 people found this helpful
I was having a terrible day with severe pain. I’ve suffered from debilitating headaches and was diagnosed with cluster headaches and occipital neuralgia. I experienced relief after years of chronic pain. Despite trying numerous treatments, this magnesium was what I had been lacking. I would like to thank God for leading me to the remedy my body needed. I hope my review assists someone else in finding what works when others fail.
Read More
7.5
Cognitive improvement
13 people found this helpful
Excellent product, top quality. The magnesium is precisely packaged and is a patented form (Magtein® = Magnesium L-Threonate), which became available in 2010. It can cross the blood-brain barrier, increasing magnesium levels in the brain by up to 15%. This has noticeably improved my cognitive ability, lessened my migraines, reduced muscle pain, and enhanced my sleep quality significantly.
Synthesis and characterization of novel denosumab/magnesium-based metal organic frameworks nanocomposite prepared by ultrasonic route as drug delivery system for the treatment of osteoporosis.
We developed a novel drug delivery system combining denosumab and magnesium within metal-organic frameworks to target osteoarthritis. The framework showed good potential for loaded drug release, delivering about 72% of denosumab in just 8 hours.
Additionally, it released magnesium ions, which are beneficial for bone formation. Our cytotoxicity tests demonstrated that the system is biocompatible and encourages cell growth over time. While our findings are promising for pain relief linked to osteoporosis, further studies are needed to confirm effectiveness in real-world scenarios.
Read More
7
Pamidronate therapy reduces bone pain
New trends in the treatment of osteogenesis imperfecta type III - own experience.
We evaluated the effects of pamidronate therapy on children with osteogenesis imperfecta type III. Over the course of treatment, we saw reductions in bone pain, alongside a significant decrease in fracture incidence.
The therapy positively impacted children's daily activities and their overall mobility. Importantly, the treatment was found to be safe, although some patients experienced mild side effects like low calcium levels and a fever. Overall, our findings suggest that bisphosphonate therapy is beneficial for management in these young patients.
Read More
7
CMT shows potential for pain relief
The efficacy of choline magnesium trisalicylate (CMT) in the management of metastatic bone pain: a pilot study.
We investigated how choline magnesium trisalicylate (CMT) helps alleviate bone pain in patients with metastatic cancer. In a carefully designed study involving 26 participants, we compared CMT against a placebo in a crossover format, measuring pain relief at multiple intervals after dosing.
While we observed a significant reduction in pain just one hour post-treatment with CMT, other comparisons showed improvements that didn't reach statistical significance. This suggested that CMT might assist in managing bone pain, potentially complementing traditional opioids, but overall effectiveness is still under exploration.
Read More
User Reviews
USERS' SCORE
Good
Based on 38 Reviews
8.2
All Reviews
Positive Reviews
Negative Reviews
9
Effective for calm
109 people found this helpful
Best Mg I've ever used! This magnesium is great! I'm a naturopath and have tried many types of magnesium. This one genuinely induces a sense of calm, balance and prepares me for sound sleep through the night. Within a few days, I noticed a change. It's been about three weeks now and my neck/muscle pain has disappeared. Very happy with this product. Thank you!
Read More
9
Chronic pain relief
48 people found this helpful
I was having a terrible day with severe pain. I’ve suffered from debilitating headaches and was diagnosed with cluster headaches and occipital neuralgia. I experienced relief after years of chronic pain. Despite trying numerous treatments, this magnesium was what I had been lacking. I would like to thank God for leading me to the remedy my body needed. I hope my review assists someone else in finding what works when others fail.
Read More
7.5
Cognitive improvement
13 people found this helpful
Excellent product, top quality. The magnesium is precisely packaged and is a patented form (Magtein® = Magnesium L-Threonate), which became available in 2010. It can cross the blood-brain barrier, increasing magnesium levels in the brain by up to 15%. This has noticeably improved my cognitive ability, lessened my migraines, reduced muscle pain, and enhanced my sleep quality significantly.
Read More
9
Improved sleep quality
11 people found this helpful
High-quality, effective magnesium! I buy magnesium for my family, especially for my dad, who struggles with joint and muscle pain and sleep issues. He takes one capsule before bed and has normalised his sleep, falling asleep easily without pain. The effect has been quickly noticeable, and we intend to continue using this form of neuromagnesium.
Read More
10
Bone pain gone
4 people found this helpful
Just awesome! I have felt very comfortable after using it, and my bone pain is gone.
Bone pain is a discomfort or ache that originates within the bones themselves and can range from mild to severe. It is different from muscle or joint pain, as it directly affects the skeletal structure. Bone pain can be caused by a variety of factors, including injuries, medical conditions such as osteoarthritis or osteoporosis, infections, or tumors. Symptoms may vary depending on the underlying cause but often include a dull, penetrating ache that may worsen with movement or pressure.
If you're experiencing persistent bone pain, it’s essential to consult with a healthcare professional for a proper diagnosis and treatment plan. Imaging tests like X-rays, MRI, or CT scans may be utilized to determine the root cause of the pain. Treatment can vary widely, ranging from medications to alleviate pain and inflammation to physical therapy or, in some cases, surgical interventions. Understanding the underlying cause is crucial to effectively managing bone pain and ensuring the best path to recovery.
Magnesium is a chemical element with the symbol Mg and atomic number 12. It is a lightweight, silvery-white metal that is a member of the alkaline earth metals group. Often classified as one of the most abundant elements in the Earth's crust, magnesium plays a crucial role in various biological functions and is essential for living organisms. In nature, magnesium can be found in large quantities, primarily in minerals such as dolomite and magnesite, and it is also present in seawater.
In terms of health benefits, magnesium is vital for numerous metabolic processes, including energy production, DNA synthesis, and muscle function. It contributes to bone health, helps regulate blood pressure, and supports bone formation by promoting the effects of vitamin D. The recommended dietary allowance (RDA) for magnesium varies by age and gender, but it is generally important to include magnesium-rich foods like leafy greens, nuts, seeds, and whole grains in your diet to ensure adequate intake. For those who may not receive enough magnesium through their diet alone, supplements are also available; however, it is advisable to consult a healthcare professional before starting any supplementation.
Magnesium plays a crucial role in bone health and may help alleviate some types of bone pain, especially if the pain is related to deficiencies. This essential mineral aids in the regulation of calcium levels in the bone, which is vital for maintaining bone density and overall strength. Some studies have suggested that adequate magnesium intake may reduce the risk of osteoporosis and bone fractures, which are common causes of long-term bone pain. However, if you are experiencing significant or persistent bone pain, it's crucial to consult with a healthcare professional to identify the underlying cause.
While magnesium may provide support for bone health, it should not be viewed as a standalone treatment for bone pain. Incorporating magnesium-rich foods, such as leafy greens, nuts, seeds, and whole grains, can be beneficial in supporting bone health. For some individuals, magnesium supplements may also be considered, but it's important to do this under medical supervision to avoid potential side effects or interactions with other medications. Additionally, a comprehensive approach that includes proper nutrition, exercise, and other lifestyle factors is essential for managing bone health effectively.
Based on user reviews, the timeline for experiencing relief from bone pain while taking magnesium supplements can vary. Many users report noticeable improvements within a matter of days to weeks. For instance, one user mentioned experiencing significant relief from muscle and neck pain within just three weeks of use Read Review. Another user highlighted that their bone pain disappeared after a short duration of usage, indicating a swift response to the supplement Read Review.
In some cases, individuals have found relief nearly immediately after starting their regimen. For example, one review noted the alleviation of muscle pain shortly after taking this form of magnesium, suggesting that the effects can be rapid for some users Read Review. Overall, while the experience varies from person to person, many users suggest that you could start to see results within a week to three weeks of consistent use.
The research indicates that there are potential supplements that can aid in managing bone pain, though further studies are needed for definitive conclusions. One such study investigated choline magnesium trisalicylate (CMT) in patients with metastatic cancer and found a significant reduction in pain just one hour post-treatment. However, the overall effectiveness of CMT compared to placebo did not reach statistical significance over time, suggesting it may be a complementary treatment rather than a standalone solution for bone pain management [3].
Additionally, another study explored a novel magnesium-based drug delivery system that aims to treat osteoporosis and may provide pain relief tied to the condition. This system combines denosumab and magnesium and shows promise in releasing beneficial ions for bone formation, but it emphasizes the necessity for further investigation in real-world applications to fully understand its effectiveness in alleviating bone pain [1]. While current findings are encouraging, they underline the need for more extensive clinical trials to establish the efficacy of these magnesium-related treatments for broader pain management strategies.
Users have reported a wide range of improvements in their symptoms after incorporating magnesium supplements into their routines. A significant number of reviewers noted quick relief from various types of pain, including muscle, joint, and bone pain. For instance, one user experienced a complete disappearance of neck and muscle pain within three weeks of starting the supplement Read Review. Others have found that their debilitating headaches and other chronic pain issues improved dramatically, even after years of struggling with them Read Review.
In addition to pain relief, many users highlighted improvements in sleep quality and overall calmness. One reviewer shared that their father, who had joint and muscle pain, was able to normalize his sleep after taking the supplement for just a few days Read Review. Overall, while individual results can vary, a considerable number of users have noted significant benefits in both physical and mental wellness with regular use of magnesium, including improvements in cognitive function and mood Read Review.
Users report various experiences regarding the combination of this magnesium supplement with other supplements for managing bone pain. Many individuals noted that they found great relief not only from bone pain but also from joint and muscle discomfort when using magnesium in conjunction with calcium and vitamin D. One reviewer mentioned the importance of magnesium for bone formation, indicating that it aids in calcium absorption and activates vitamin D, thus promoting bone health and reducing osteoporosis risk Read Review. Another user highlighted that when magnesium is paired with calcium, it can significantly increase bone mineral density, which is crucial for overall bone strength Read Review.
Users also express gratitude for the effectiveness of magnesium in enhancing overall well-being and reducing chronic pain symptoms when used as a part of a broader supplement regimen. In one case, a user shared how their mother saw improvements in her condition after taking magnesium alongside other medications, demonstrating magnesium's versatility in pain management Read Review. This suggests that users often experience amplified benefits by combining magnesium with other essential nutrients, leading to significant improvements in bone pain and overall health.
The optimal dose of magnesium for treating bone pain is not definitively established based on the available research. A study investigating the effects of choline magnesium trisalicylate (CMT) on bone pain in patients with metastatic cancer demonstrated a significant reduction in pain just one hour after treatment. However, this study did not specify an exact dosage, indicating that while magnesium may provide relief, further exploration is warranted to determine the most effective dosing regimen for managing bone pain [3].
Additionally, there is evidence that magnesium ions contribute positively to bone formation, particularly when delivered through innovative systems like metal-organic frameworks, which facilitate the targeted release of both magnesium and drugs such as denosumab. While these findings highlight the potential benefits of magnesium in treating bone pain, including conditions such as osteoporosis, more comprehensive studies are needed to confirm optimal dosing and real-world efficacy [1]. As of now, individuals considering magnesium supplementation for bone pain should consult a healthcare professional for personalized recommendations.
9
Effective for calm
109 people found this helpful
Best Mg I've ever used! This magnesium is great! I'm a naturopath and have tried many types of magnesium. This one genuinely induces a sense of calm, balance and prepares me for sound sleep through the night. Within a few days, I noticed a change. It's been about three weeks now and my neck/muscle pain has disappeared. Very happy with this product. Thank you!
10
Bone pain gone
4 people found this helpful
Just awesome! I have felt very comfortable after using it, and my bone pain is gone.
9
Pregnancy relief
3 people found this helpful
Magnesium Threonate is high quality and highly absorbed, though slightly pricey. Despite this, I find it worth following for discounts. It contains only quality ingredients and is perfect for breastfeeding. It quickly alleviates muscle pain during pregnancy within just fifteen minutes of taking it. Highly recommended after trying various types; consult a doctor for use.
9
Chronic pain relief
48 people found this helpful
I was having a terrible day with severe pain. I’ve suffered from debilitating headaches and was diagnosed with cluster headaches and occipital neuralgia. I experienced relief after years of chronic pain. Despite trying numerous treatments, this magnesium was what I had been lacking. I would like to thank God for leading me to the remedy my body needed. I hope my review assists someone else in finding what works when others fail.
9
Improved sleep quality
11 people found this helpful
High-quality, effective magnesium! I buy magnesium for my family, especially for my dad, who struggles with joint and muscle pain and sleep issues. He takes one capsule before bed and has normalised his sleep, falling asleep easily without pain. The effect has been quickly noticeable, and we intend to continue using this form of neuromagnesium.
7.5
Cognitive improvement
13 people found this helpful
Excellent product, top quality. The magnesium is precisely packaged and is a patented form (Magtein® = Magnesium L-Threonate), which became available in 2010. It can cross the blood-brain barrier, increasing magnesium levels in the brain by up to 15%. This has noticeably improved my cognitive ability, lessened my migraines, reduced muscle pain, and enhanced my sleep quality significantly.
7.5
Bone density boost
1 people found this helpful
Magnesium is essential for bone formation, assisting calcium absorption and activating vitamin D in the kidneys, vital for bone health. Adequate magnesium levels are linked to increased bone density and decreased injury risk, particularly osteoporosis in postmenopausal women.
9
Bone health support
1 people found this helpful
Magnesium positively impacts bone growth, normalises heart rate, lowers blood pressure, and regulates blood sugar levels while eliminating muscle cramps and reducing joint pain. When combined with calcium, it increases bone mineral density. The quality and ingredients are excellent.
10
Convulsions improved
3 people found this helpful
This is salvation! I gave this magnesium to my mother, who experienced tonic convulsions exacerbated by post-COVID complications. Her condition has improved significantly since she began taking it with other medications. I’m thrilled to find a magnesium form that acts quickly and effectively.
7
CMT shows potential for pain relief
The efficacy of choline magnesium trisalicylate (CMT) in the management of metastatic bone pain: a pilot study.
We investigated how choline magnesium trisalicylate (CMT) helps alleviate bone pain in patients with metastatic cancer. In a carefully designed study involving 26 participants, we compared CMT against a placebo in a crossover format, measuring pain relief at multiple intervals after dosing.
While we observed a significant reduction in pain just one hour post-treatment with CMT, other comparisons showed improvements that didn't reach statistical significance. This suggested that CMT might assist in managing bone pain, potentially complementing traditional opioids, but overall effectiveness is still under exploration.
7
Promising drug delivery for osteoporosis
Synthesis and characterization of novel denosumab/magnesium-based metal organic frameworks nanocomposite prepared by ultrasonic route as drug delivery system for the treatment of osteoporosis.
We developed a novel drug delivery system combining denosumab and magnesium within metal-organic frameworks to target osteoarthritis. The framework showed good potential for loaded drug release, delivering about 72% of denosumab in just 8 hours.
Additionally, it released magnesium ions, which are beneficial for bone formation. Our cytotoxicity tests demonstrated that the system is biocompatible and encourages cell growth over time. While our findings are promising for pain relief linked to osteoporosis, further studies are needed to confirm effectiveness in real-world scenarios.
References
Alsaikhan F, Mahmoud MZ, Suliman M. Synthesis and characterization of novel denosumab/magnesium-based metal organic frameworks nanocomposite prepared by ultrasonic route as drug delivery system for the treatment of osteoporosis. Front Bioeng Biotechnol. 2023;11:1153969. doi:10.3389/fbioe.2023.1153969
Jakubowska-Pietkiewicz E, Chlebna-Sokół D. New trends in the treatment of osteogenesis imperfecta type III - own experience. Ortop Traumatol Rehabil. 2008;10:593.
Johnson JR, Miller AJ. The efficacy of choline magnesium trisalicylate (CMT) in the management of metastatic bone pain: a pilot study. Palliat Med. 1994;8:129.